Antiviral Drug Allergy

Antiviral drugs used to treat HIV and hepatitis C are common causes of delayed drug hypersensitivities for which many of the more severe reactions have been recently shown to be immunogenetically mediated such as abacavir hypersensitivity where HLA-B*57:01 is now used routinely as a screening test to exclude patients carrying this allele from abacavir prescription. Most antiviral drug allergies consist of mild to moderate delayed rash without other serious features (e.g. fever, mucosal involvement, blistering rash, organ impairment. In these cases treatment can be continued with careful observation and symptomatic management and the discontinuation rate is low

The Ph.D. as a learning process

The main question being addressed by this research was 'how do postgraduate research students experience the process of doing a Ph.D.?' The way this question was investigated was to discover how the students involved solved the problems which confronted them when doing a research degree. Seven case studies of Ph.D. students and their supervisors are reported. The student and supervisor pairs came from different disciplines and two universities. The case studies were conducted through interviews and the repertory grid was used as a tool throughout the three years of field work. Additional methods used included rating forms and free writing. The focus of the study was the postgraduates' changing perceptions of their Ph.D. The topics investigated in order to monitor these changes included: 1) The students' relationship with their supervisors 2) The difference between what they expected to accomplish in a given time and what they actually did accomplish 3) Writing up the results of their work. Results indicated that the process was similar in these respects for Arts and Science students. It was found that: a - it was necessary for students to develop an ability to evaluate their own work. The rate of this development appeared to be related to the degree to which the students were allowed to remain dependent on their supervisors. It is suggested that some kind of 'weaning' process should be introduced into the student and supervisor relationship as the postgraduates develop the self-confidence to monitor their own work. b - The students' ability to estimate accurately what work they could accomplish in a given period of time did not improve over the three years. The observed discrepancies between what the students expected to achieve and what they actually did achieve are used as the basis for describing a hypothetical mechanism by which plans are revised as goals and time limits are adjusted. c - Writing helped to clarify thinking but was seen by the postgraduates as a difficult activity and of minor importance. This was because it served specific functions. At the ideas generating stage of the work writing helped the students to think more creatively and at the presentation of results stage it helped to organize their work into a coherent whole. d - Their enthusiasm for their Ph.D. diminished due to the length of time they had to spend working on a single problem. The postgraduates' perceptions changed from seeing the Ph.D. as something special and unique to seeing it as a job of work that had to be completed. Throughout this thesis, the students' changing perceptions of their Ph.D.s are presented as vital to completion of the higher degree course. All these points taken together are presented as important in developing the skills needed to engage in professional research. They are suggested to be significant aspects of the Ph.D. as a learning process

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change

Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer

Background Emergency presentation is recognized to be associated with poorer cancer-specific survival following curative resection for colorectal cancer. The present study examined the hypothesis that an enhanced systemic inflammatory response, prior to surgery, might explain the impact of emergency presentation on survival. Methods In all, 188 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 55 (29%) presented as emergencies. The systemic inflammatory response was assessed using the Glasgow Prognostic Score (mGPS), which is the combination of an elevated C-reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L). Results In the emergency group, tumor stage was greater (P < 0.01), more patients received adjuvant therapy (P < 0.01) more patients had an elevated mGPS (P < 0.01), and more patients died of their disease (P < 0.05). The minimum follow-up was 12 months; the median follow-up of the survivors was 48 months. Emergency presentation was associated with poorer 3-year cancer-specific survival in those patients aged 65 to 74 years (P < 0.01), in both males and females (P < 0.05), in the deprived (P < 0.01), in patients with tumor-node-metastasis (TNM) stage II disease (P < 0.01), in those who received no adjuvant therapy (P < 0.01), and in the mGPS 0 and 1 groups (P < 0.05) groups. On multivariate survival analysis of patients undergoing potentially curative surgery for TNM stage II colon cancer, emergency presentation (P < 0.05) and mGPS (P < 0.05) were independently associated with cancer-specific survival. Conclusions These results suggest that emergency presentation and the presence of systemic inflammatory response prior to surgery are linked and account for poorer cancer-specific survival in patients undergoing potentially curative surgery for colon cancer. Both emergency presentation and an elevated mGPS should be taken into account when assessing the likely outcome of these patients

Renal crystal deposits and histopathology in patients with cystine stones

We have biopsied the papillae of patients who have cystine stones asking if this stone type is associated with specific tissue changes. We studied seven cystine stone formers (SF) treated with percutaneous nephrolithotomy using digital video imaging of renal papillae for mapping and obtained papillary biopsies. Biopsies were analyzed by routine light and electron microscopy, infrared spectroscopy, electron diffraction, and micro-CT. Many ducts of Bellini (BD) had an enlarged ostium, and all such were plugged with cystine crystals, and had injured or absent lining cells with a surrounding interstitium that was inflamed to fibrotic. Crystal plugs often projected into the urinary space. Many inner medullary collecting ducts (IMCD) were dilated with or without crystal plugging. Apatite crystals were identified in the lumens of loops of Henle and IMCD. Abundance of interstitial Randall's plaque was equivalent in amount to that of non-SF. In the cortex, glomerular obsolescence and interstitial fibrosis exceeded normal. Cystine crystallizes in BD with the probable result of cell injury, interstitial reaction, nephron obstruction, and with the potential of inducing cortical change and loss of IMCD tubular fluid pH regulation, resulting in apatite formation. The pattern of IMCD dilation, and loss of medullary structures is most compatible with such obstruction, either from BD lumen plugs or urinary tract obstruction from stones themselves

Transport Properties near the z=2 Insulator-Superconductor Transition

We consider here the fluctuation conductivity near the point of the insulator-superconductor transition in a system of regular Josephson junction arrays in the presence of particle-hole asymmetry or equivalently homogeneous charge frustration. The transition is characterised by the dynamic critical exponent $z=2$, opening the possibility of the perturbative renormalization-group (RG) treatment. The quartic interaction in the Ginzburg-Landau action and the coupling to the Ohmic heat bath, giving the finite quasiparticle life-time, lead to the non-monotonic behavior of the dc conductivity as a function of temperature in the leading logarithmic approximation.Comment: Revised version for publication. To appear in PR

Strobilurin fungicides in house dust: is wallboard a source?

Strobilurin fungicides are used primarily in fruits and vegetables, but recently, a patent was issued for one strobilurin fungicide, azoxystrobin, in mold-resistant wallboard. This raises concerns about the potential presence of these chemicals in house dust and potential exposure indoors, particularly in young children. Furthermore, recent toxicological studies have suggested that strobilurins may cause neurotoxicity. Currently, it is not clear whether or not azoxystrobin applications in wallboard lead to exposures in the indoor environments. The purpose of this study was to determine if azoxystrobin, and related strobilurins, could be detected in house dust. We also sought to characterize the concentrations of azoxystrobin in new wallboard samples. To support this study, we collected and analyzed 16 new dry wall samples intentionally marketed for use in bathrooms to inhibit mold. We then analyzed 188 house dust samples collected from North Carolina homes in 2014–2016 for azoxystrobin and related strobilurins, including pyraclostrobin, trifloxystrobin, and fluoxastrobin using liquid chromatography tandem mass spectrometry. Detection frequencies for azoxystrobin, pyraclostrobin, trifloxystrobin, and fluoxastrobin ranged from 34–87%, with azoxystrobin being detected most frequently and at the highest concentrations (geometric mean = 3.5 ng/g; maximum = 10,590 ng/g). Azoxystrobin was also detected in mold-resistant wallboard samples, primarily in the paper covering where it was found at concentrations up to 88.5 µg/g. Cumulatively, these results suggest that fungicides present in wallboard may be migrating to the indoor environment, leading to exposure in the residences that would constitute a separate exposure pathway independent of dietary exposures

Finding optimal strategies for minimum-error quantum-state discrimination

We propose a numerical algorithm for finding optimal measurements for quantum-state discrimination. The theory of the semidefinite programming provides a simple check of the optimality of the numerically obtained results.Comment: 4 pages, 2 figure